# Biohub ESM (ChatGPT App)

> Understand proteins with ESM

- Type: app
- Publisher: Chan Zuckerberg Biohub, Inc. (official)
- Categories: Research
- Website: https://chatgpt.com/plugins/plugin_asdk_app_6abdcb3d2970819186a0c7a25c953c4b
- Open in ChatGPT: https://chatgpt.com/plugins/plugin_asdk_app_6abdcb3d2970819186a0c7a25c953c4b
- Version: 0.4.3
- Listed: 2026-10-15

## About

Biohub ESM helps you understand proteins from a name, sequence, or file: explore mutation landscapes, interpret what ESMC sees, predict and view all-atom structures, and discover related proteins. It chooses the right ESM workflow, preserves confidence and provenance, and presents results automatically. It also supports MSA-guided and modified-complex workflows, and private or large-scale compute routing. Supported protein sequences use the Biohub MCP viewer. Complexes and exact prediction files use a separate molecular viewer when available, with an agent-generated static rendering as a last resort where local rendering tools are available. Managed inference requires a Biohub API key and may incur usage charges. Predictions support research hypotheses, not experimental conclusions.

## How to use

1. **Add it in ChatGPT** Open Biohub ESM in ChatGPT's Plugin directory (button above), select + to add it and sign in if asked.

2. **Use it in a chat** Type @ in the composer and pick Biohub ESM, or start your message with its name. ChatGPT may also suggest it when it fits what you ask.

## Skills

- **Biohub ESM Router**: Route ESMC, ESMFold2, Atlas, and compute
- **Biohub ESM Setup**: Install, preflight, and diagnose ESM access
- **ESM Atlas**: Search proteins, features, structures, and clusters
- **ESMC**: Represent proteins and score sequence mutations
- **ESMFold2**: Fold all-atom biomolecular complexes

## Example prompts

- "Map the mutational landscape of PETase and show me where it is most constrained or tolerant."
- "Show me what ESMC has learned about ATP synthase and map the strongest features onto its structure."
- "Model how a modified GLP-1 peptide with a lipid linker might engage GLP-1R, then show me the complex."

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Source: https://chatgptplugins.directory/apps/biohub-esm · Index: https://chatgptplugins.directory/llms.txt · Independent and community-run. Not affiliated with or endorsed by OpenAI. ChatGPT is a trademark of OpenAI.