Connect your B12 account to research chemical synthesis strategies, assess routes, and develop a selected strategy into a detailed route. Compare literature evidence, starting materials, reaction steps, and uncertainties. Revisit saved assessments and planning results across conversations. Research and route-development availability depends on your account configuration. Proposed routes require expert review and experimental validation.
Runs locally: needs the ChatGPT desktop app or Codex with local execution enabled.
How to use
- 1Add it in ChatGPT
Open Selenium in ChatGPT's Plugin directory (button above), select + to add it and sign in if asked.
- 2Use it in a chat
Type @ in the composer and pick Selenium, or start your message with its name. ChatGPT may also suggest it when it fits what you ask.
Skills 2
- selenium-paper-to-route
Read a synthesis paper and supporting information, describe its route in detail, and hand the exact target and source-grounded strategy to Selenium RouteDev. Use when the user wants to reproduce or adapt a published route; not for unrestricted retrosynthesis.
- selenium-route-search
Plan chemical syntheses via the B12 Selenium route-search API. Use when asked to find synthetic routes / retrosynthesis for a molecule, assess whether a target is makeable, or compare disconnection strategies. Submits a target (SMILES), polls the async job, and returns ranked route families with feasibility and commercial-availability data.
Things to ask
- “Research synthesis routes for my target molecule, compare the evidence, and show me the credit cost before starting.”
- “Read this synthesis paper and supporting information, explain the route, and help me develop a route for my target.”
- “Open my latest synthesis assessment and compare its route families, starting materials, and key uncertainties.”