Biohub ESM helps you understand proteins from a name, sequence, or file: explore mutation landscapes, interpret what ESMC sees, predict and view all-atom structures, and discover related proteins. It chooses the right ESM workflow, preserves confidence and provenance, and presents results automatically. It also supports MSA-guided and modified-complex workflows, and private or large-scale compute routing. Supported protein sequences use the Biohub MCP viewer. Complexes and exact prediction files use a separate molecular viewer when available, with an agent-generated static rendering as a last resort where local rendering tools are available. Managed inference requires a Biohub API key and may incur usage charges. Predictions support research hypotheses, not experimental conclusions.
How to use
- 1Add it in ChatGPT
Open Biohub ESM in ChatGPT's Plugin directory (button above), select + to add it and sign in if asked.
- 2Use it in a chat
Type @ in the composer and pick Biohub ESM, or start your message with its name. ChatGPT may also suggest it when it fits what you ask.
Skills 5
- Biohub ESM Router
Route ESMC, ESMFold2, Atlas, and compute
- Biohub ESM Setup
Install, preflight, and diagnose ESM access
- ESM Atlas
Search proteins, features, structures, and clusters
- ESMC
Represent proteins and score sequence mutations
- ESMFold2
Fold all-atom biomolecular complexes
Things to ask
- “Map the mutational landscape of PETase and show me where it is most constrained or tolerant.”
- “Show me what ESMC has learned about ATP synthase and map the strongest features onto its structure.”
- “Model how a modified GLP-1 peptide with a lipid linker might engage GLP-1R, then show me the complex.”